Cholesterol and Heart Disease
by Cheryl Reinhart
Heart disease is the leading cause of death in the United States and high cholesterol levels play a major role in this process. Even though we need cholesterol, too much of it is a major risk factor for heart attacks and strokes. Understanding our cholesterol levels can be complex and confusing. When we ask patients what their cholesterol levels are they usually give us the total cholesterol. The total cholesterol is only part of the story. It includes the:
- HDL ("good") cholesterol
- LDL (“bad”) cholesterol
- Triglycerides (“ugly”) sugar
Understanding Cholesterol
Cholesterol is a soft, waxy, “fat’ that is needed by the body for functions such as building cell membranes and making hormones. The problem is if there is too much cholesterol it can build up in the walls of our arteries causing a hard substance called plaque that can block our arteries and cause a heart attack or a stroke. The LDL is called “bad” cholesterol because it causes build-up on the artery walls. The HDL is called “good” cholesterol because it carries the cholesterol (LDL) away from the artery walls and out of the body.
Triglycerides (Tg), a special fat, are also associated with heart disease. They travel in the blood to be used for energy or stored as fat. High Tg levels are associated with obesity, diabetes, insulin resistance and low levels of the good cholesterol- HDL.
What causes high cholesterol?
The 2 main sources of cholesterol and triglycerides in the body are from the foods we eat and what is made by the liver and other cells in the body. Other factors contributing to high cholesterol levels include poor diet, obesity, heredity, sedentary lifestyle, age, gender, liver or chronic kidney disease, steroids and estrogen, diabetes and low thyroid. Triglycerides primarily arise from sugar.
What will happen if my levels are high?
Over time high cholesterol levels can lead to plaque formation that can narrow the artery wall space or break open causing blood clots to form which can cut off blood flow to the heart or brain. Plaque can also make arteries stiffer so they won’t stretch when increased blood flow is needed such as with exercise.
What should my numbers be?
- LDL optimally would be 100 or <70 if diabetic or if you have heart disease. Borderline is 100-130. We like for our patients to be as close to 100 as possible especially if you are at intermediate risk.
- HDL >40 for a man and >50 for a woman
- Triglycerides <150. Borderline high is 150-199, high 200-499 and >500 very high
To see if you are at intermediate risk or high risk for a heart attack or stroke, click here.
Read more about cholesterol and heart disease.
Cardiac PET Stress Testing
By Dr. James Rellas
"Doctor, I had a nuclear stress test months ago, traveled on business, and 3 months later suffered a hear t attack! How can that happen?"
There are many misperceptions regarding stress testing and what the results guarantee. Tests in general can either be good at picking up abnormal patients or correctly identifying normal patients. You can’t have it both ways, until now!
Stress echocardiogram and nuclear stress testing have been the norm for years. These tests are used to identify patients with significant blockages that need immediate attention. Hopefully, at the same time we don’t misidentify healthy patients and send them off for unnecessary and potentially dangerous additional testing. For those of you who remember statistics, the sensitivity of these tests vary in studies between 80% and 90%. Specificity is worse at 75-88%.
The “GOLD STANDARD” to assess how well stress echocardiograms and nuclear testing is doing has been Cardiac PET testing. Used primarily as a research tool this “GOLD STANDARD” has been unavailable to patient care until recently. Previously, one needed a cyclotron to obtain the nuclear isotope, rubidium-82, for PET imaging. We now have the ability to bring the rubidium-82 to the office of a nuclear cardiologist using a generator that produces rubidium-82 (from decaying strontium) for one month. In addition, equipment is more reasonably priced allowing nuclear cardiologists to offer the “GOLD STANDARD” in their office.
Read more about cardiac PET stress testing.
Cartoon from Medical Economics Magazine, August 6, 2010. |